WebBasigin (BSG, CD147) is a multifunctional protein involved in cancer cell survival, mostly by controlling lactate transport through its interaction with monocarboxylate transporters … WebMar 21, 2024 · BSG (Basigin (Ok Blood Group)) is a Protein Coding gene. Diseases associated with BSG include Severe Acute Respiratory Syndrome and Ameloblastoma. …
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WebBasigin (BSG), also named CD147/EMMPRIN, a member of the immunoglobulin family of transmembrane proteins, exerts a wide range of both physiological and pathological functions [1,2,3,4]. Of particular note, BSG regulates the expression and cell surface localization of monocarboxylate transporters-1 (MCT1) and MCT4, allowing the efflux of … WebCD147 is expressed on a variety of cell types (e.g., hematopoietic, epithelial, and endothelial cells) and at varying levels (PMID: 32968061). Increased expression of CD147 occurs in many tumors. CD147 is a pleiotropic molecule that plays an important role in fetal, neuronal, lymphocyte and extracellular matrix development (PMID: 17945211).
WebSep 21, 2024 · Recently, CD147 or Basigin (BSG) has been identified as potential additional host receptor for viral entry . This highly glycosylated transmembrane protein is also present in many tissues, including the testis, uterus, ovaries and placenta. The functional role and importance of this new (co-) receptor for SARS-CoV-2 is not understood. WebDec 27, 2024 · Background BSG (CD147) is a member of the immunoglobulin superfamily that shows roles for potential prognostics and therapeutics for metastatic cancers and SARS-CoV-2 invasion for COVID-19. The susceptibility of malignant cancers to SARS-CoV-2 as well as the correlations between disease outcome and BSG expression in tumor …
WebSummary of BSG (CD147, EMMPRIN, EMPRIN, OK) expression in human tissue. Membranous expression in most cell types, including glandular cells, cells in seminiferous ducts, renal tubules, cardiac myocytes and vascular endothelium in the brain. WebAbcam’s Human BSG (CD147) in vitro ELISA (Enzyme-Linked Immunosorbent Assay) kit is designed for the accurate quantitative measurement of Human BSG in cell culture supernatants, serum, (heparin, EDTA), saliva, urine and Human milk. A BSG specific mouse monoclonal antibody has been precoated onto 96-well plates.
WebJan 11, 2024 · Among the most prominent claims for an alternate SARS-CoV-2 host receptor comes from a report identifying basigin (CD147) as …
WebJun 4, 2024 · We performed RNA sequencing and explored available RNA-Seq databases to study gene expression and co-expression of ACE2, CD147 ( BSG ), and CD26 ( DPP4) and their direct and indirect molecular partners in primary human bronchial epithelial cells, bronchial and skin biopsies, bronchoalveolar lavage fluid, whole blood, peripheral blood … pork scratching gifts ukNotably, CD147 antibody-mediated blocking significantly reduced the expression of S100A9, and S100A8 on megakaryocytes following incubation with SARS-CoV-2. These data indicate that megakaryocytes and platelets actively take up SARS-CoV-2 virions, likely via an ACE-2-independent mechanism. See more Basigin (BSG) also known as extracellular matrix metalloproteinase inducer (EMMPRIN) or cluster of differentiation 147 (CD147) is a protein that in humans is encoded by the BSG gene. This protein is a determinant for … See more Basigin is a member of the immunoglobulin superfamily, with a structure related to the putative primordial form of the family. As members of the … See more It have been shown that Atorvastatin suppresses CD147 and MMP-3 expression. Statins altered CD147 expression, structure and function. See more The host-cell-expressed basigin (CD147) may bind spike protein of SARS-CoV-2 and possibly be involved in host cell invasion. Subsequently, … See more Basigin has been shown to interact with Ubiquitin C. Basigin has been shown to form a complex with See more It has recently (November 2011) been found that basigin is a receptor that is essential to erythrocyte invasion by most strains of See more • Muramatsu T, Miyauchi T (July 2003). "Basigin (CD147): a multifunctional transmembrane protein involved in reproduction, neural function, inflammation and tumor invasion". Histology and Histopathology. 18 (3): 981–987. doi:10.14670/HH-18.981 See more pork scratching giftsWebFeb 5, 2024 · CD147 is a Novel Interaction Partner of Integrin alphaMbeta2 Mediating Leukocyte and Platelet Adhesion. The expression of SARS-CoV-2 receptor ACE2 and … sharp health plan addressWebJan 10, 2024 · BSG (CD147) Serum Level and Genetic Variants Are Associated with Overall Survival in Acute Myeloid Leukaemia Authors Piotr Łacina 1 , Aleksandra Butrym 2 , Eliza Turlej 3 4 , Martyna Stachowicz-Suhs 3 , Joanna Wietrzyk 3 , Grzegorz Mazur 5 , Katarzyna Bogunia-Kubik 1 Affiliations pork scratching advent calendar 2021WebWe identified BSG/CD147 and ACE2 receptors as key mediators of spike binding activity in human iPS cell-derived podocytes. These results show that SARS-CoV-2 can infect … sharp healthcare urgent care santeeWebNiclosamide는 SARS-CoV-2 유도 CD147을 효과적으로 억제합니다 위에서 언급한 바와 같이, RNA-seq는 SARS-CoV-2가 BSG 48의 발현을 촉진한다는 것을 밝혀냈습니다. 여기서 우리는 a) BSG 발현의 증가를 확인하고 b) SARS-CoV-2에 … sharp healthcare w2WebMar 29, 2024 · 为了阐明除ACE2以外的受体和蛋白酶在SARS-CoV-2感染中的功能，该研究通过使用过表达ACE2的iPS（ACE2 iPS）和CRISPRi系统抑制了BSG、CTSB和TMPRSS2基因的表达水平，并设计了针对这些基因的sgRNA。用表达sgRNAs、mKate2和抗病毒基因的质粒电转染iPS，如下图所示。 编辑. 编辑 sharp health plan one time payment