Web13 de abr. de 2024 · Natural selection on EPAS1 (HIF2α) associated with low hemoglobin concentration in Tibetan highlanders. PNAS, 107(25): 11459-11464. 16. Deng L, Zhang D, Richards E, Tang X, Long F, Fang J, Wang Y. (2009) Constructing an initial map of transmission distortion based on high density HapMap SNPs across the human … Web19 de ago. de 2024 · The 5′-untranslated regions IRE of IRP2 also exists in the Hif2α mRNA and serves as a point of Hif2 regulation . These pieces of evidence powerfully hinted the possible existence of IRP2-Hif1α/Hif2α axis. Recently, Li et al. identified that IRP2-Hif1α/Hif2α axis is strongly correlated with the regulation of energy metabolic switch.
【论文导读】ROS介导的PERK-eIF2α-ATF4通过激活CHOP-DR5 ...
Web24 de mar. de 2024 · In summary, HIF1α and HIF2α regulate glioblastoma malignant progression through the EGFR–PI3K/AKT pathway via a positive feedback mechanism under the effects of Sox2 and Klf4, which provides a ... WebIn response to different environmental stresses, eIF2α phosphorylation represses global translation coincident with preferential translation of ATF4, a master regulator controlling … church of scotland bookshop glasgow
eIF2 调控 Cell Signaling Technology
Web低氧诱导因子 (HIF) 是细胞应对缺氧所必需的 (1,2)。在正常氧条件下,HIF 的 α 亚基由 von Hippel-Lindau (VHL) 蛋白泛素化并且在泛素/蛋白酶体通路中降解 (1,2)。缺氧会抑制 α 亚 … Web13 de abr. de 2024 · 细胞内信号通路 . ... 鼠和人类癌细胞系中的pdl1表达;抑制了ccl2和ccl5的分泌以及cd8 t细胞和nk细胞的肿瘤浸润;hif2α可通过趋化因子cxcl1的转录调节诱导肿瘤促进中性粒细胞的募集;上述描述了缺氧诱导的癌细胞中的hif信号传导如何影响与免疫细 … Web25 de nov. de 2024 · We describe the use of belzutifan, a potent and selective small-molecule inhibitor of the protein hypoxia-inducible factor 2α (HIF2α), in a patient with … church of scotland church closures